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Consensus statement by the French Society of Endocrinology (SFE) and French Society of Pediatric Endocrinology & Diabetology (SFEDP) on diagnosis of Cushing’s syndrome  Cushing’s syndrome results from prolonged exposure to glucocorticoids, leading to morbidity and, without treatment, to high mortality. Except in case of exposure to exogenous glucocorticoids, it is a rare pathology, with incidence of 1.2–5 per million per year and prevalence of 39–79 per million, depending on series. It may have various causes: pituitary or ectopic ACTH hypersecretion, or glucocorticoid hypersecretion due to adrenal lesion(s). Pituitary-dependent Cushing’s syndrome (Cushing’s disease) is the most frequent etiology, although studies of incidence and prevalence are few and generally limited by small samples sizes. Cushing’s syndrome mostly affects adults, with a median age of 41 years at diagnosis, and marked female predominance of 3:1 . ACTH-dependent Cushing’s syndrome is the most frequent form, at 71–82% , including 86–92% of patients with Cushing’s disease. Ectopic ACTH secretion accounts for 5–14% of cases of Cushing’s syndrome. Adrenal (ACTH-independent) Cushing’s syndrome is diagnosed in 18–40% of cases, mainly due to cortisol-producing adenoma (64–72%) and secreting adrenocortical carcinoma (19–23%). Micro- and macronodular hyperplasia each account for less than 2% of cases. Download [Vous devez être Inscrit et Connecté pour voir les liens] Or [Vous devez être Inscrit et Connecté pour voir les liens]
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